Language/Jezik: ENG/SLO


Systems Medicine Conference in Slovenia

Systems Medicine Conference in Slovenia: National Awareness Event,12th CFGBC Symposium and “Systems Medicine” Workshop took place from June 8th-9th 2017 at Hotel Slon, Ljubljana, Slovenia.

CASyM winter school of Systems Medicine

CASyM winter school of Systems Medicine took place between March 29th and April 1st 2017 in Ljubljana, Slovenia and is entitled »The 3rd SysBioMed hands-on tutorial: Systems Medicine Approaches in Personalized Medicine«

ELIXIR-SI launch & 11TH CFGBC Symposium

The event with motto “Data for Life” took place from September 20th - 21st 2016 at Cankarjev dom and the Faculty of Medicine, University of Ljubljana, Slovenia.

CFGBC: Glavne publikacije

Glavne publikacije

  1. Režen T, Juvan P, Fon Tacer K, Kuzman D, Roth A, Pompon D, Aggerbeck LP, Meyer UA, Rozman D (2008) The Sterolgene v0 cDNA microarray: a systemic approach to studies of cholesterol homeostasis and drug metabolism. BMC Genomics 9:76.
    link, pdf
  2. Korošec T, Ačimovič J, Seliškar M, Kocjan D, Tacer KF, Rozman D, Urleb U (2008) Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14α-demethylase (CYP51). Bioorg Med Chem 16(1):209-21.
  3. Režen T, Contreras JA, Rozman D (2007) Functional genomics approaches to studies of the cytochrome p450 superfamily. Drug Metab Rev 39(2-3):389-99.
    link, preprint pdf
  4. Fon Tacer K, Kuzman D, Seliškar M, Pompon D, Rozman D (2007) TNF-α interferes with lipid homeostasis and activates acute and proatherogenic processes. Physiol Genomics 31(2):216-27.
    link, preprint pdf, supplement pdf
  5. Lepesheva GI, Seliškar M, Knutson CG, Stourman NV, Rozman D, Waterman MR (2007) Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET. Arch Biochem Biophys 464(2):221-7.
  6. Seliškar M, Rozman D (2006) Mammalian cytochromes P450 - Importance of tissue specificity. Biochim Biophys Acta 1770(3):458-66.
    link, preprint pdf
  7. Fink M, Ačimovič J, Režen T, Tanšek N, Rozman D (2005) Cholesterogenic lanosterol 14α-demethylase (CYP51) is an immediate early response gene. Endocrinology 146(12):5321-31.
    link, preprint pdf
  8. Van Driessche N, Demšar J, Booth EO, Hill P, Juvan P, Zupan B, Kuspa A, Shaulsky G (2005) Epistasis analysis with global transcriptional phenotypes. Nat Genet 37(5):471-7.
  9. Juvan P, Demšar J, Shaulsky G, Zupan B (2005) GenePath : from mutations to genetic networks and back. Nucleic Acids Res 33:749-52.
  10. Cotman M, Ježek D, Fon Tacer K, Frangez R, Rozman D (2004) A functional cytochrome P450 lanosterol 14α-demethylase CYP51 enzyme in the acrosome: transport through the Golgi and synthesis of meiosis-activating sterols. Endocrinology 145(3):1419-26.
  11. Zupan B, Demšar J, Bratko I, Juvan P, Halter JA, Kuspa A, Shaulsky G (2003) GenePath : a system for automated construction of genetic networks from mutant data. Bioinformatics 19(3):383-9.
  12. Zupan B, Bratko I, Demšar J, Juvan P, Curk T, Borštnik U, Beck JR, Halter J, Kuspa A, Shaulsky G (2003) GenePath : a system for inference of genetic networks and proposal of genetic experiments. Artif Intell Med 29:107-30.
    preprint pdf
  13. Halder SK, Fink M, Waterman MR, Rozman D (2002) A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14α-demethylase gene (CYP51). Mol Endocrinol 16(8):1853-63.
    link, preprint pdf
  14. Debeljak N, Horvat S, Vouk K, Lee M, Rozman D (2000) Characterization of the mouse lanosterol 14α-demethylase (CYP51), a new member of the evolutionarily most conserved cytochrome P450 family. Arch Biochem Biophys 379(1):37-45.
  15. Rozman D, Fink M, Fimia GM, Sassone-Corsi P, Waterman MR (1999) Cyclic adenosine 3',5'-monophosphate(cAMP)/cAMP-responsive element modulator (CREM)-dependent regulation of cholesterogenic lanosterol 14α-demethylase (CYP51) in spermatids. Mol Endocrinol 13(11):1951-62.
  16. Rozman D, Strömstedt M, Tsui LC, Scherer SW, Waterman MR (1996) Structure and mapping of the human lanosterol 14α-demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes. Genomics 38(3):371-81.
  17. Strömstedt M, Rozman D, Waterman MR (1996) The ubiquitously expressed human CYP51 encodes lanosterol 14α-demethylase, a cytochrome P450 whose expression is regulated by oxysterols. Arch Biochem Biophys 329(1):73-81.
2006 - University of Ljubljana, Faculty of Medicine, Center for Functional Genomics and Bio-chips.